Everything. Everyone. Everywhere...Ends. Story elements established in the first four seasons reach a series of emotional climaxes, with Ruth overwhelmed by her mentally fragile husband George, Nate struggling to reaffirm his relationship with Brenda while raising his daughter Maya, David and Keith longing for children of their own, Claire trying to broaden her horizons, and Federico attempting to fill the void left by Vanessa. By season's end, all will come to embrace the cycle of life—birth, death and rebirth—in ways that are both unique and interconnected.